求一篇有关多酚类的英文文献,最好附有中文翻译。有重谢!
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发布时间：2022-04-23 23:46
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时间：2022-05-03 08:25
Inhibitory effect of tea polyphenols on renal cell apoptosis in rat test subjects suffering from cyclosporine-inced chronic nephrotoxicity
Objective To investigate the inhibitory effect of tea polyphenols on renal cell apoptosis in rat test subjects suffering from cyclosporine A (CsA)-inced chronic nephrotoxicity.Methods Four groups of rats with CsA-inced chronic nephrotoxicity were respectively treated with vehicle olive oil, tea polyphenols, CsA and tea polyphenols plus CsA. At the end of the 28th day of treatment, 24 hours urine and blood samples were obtained, and the animals were then sacrificed.The serum and urine samples were analysed for creatinine clearance, and kidney tissue was used for pathologic analysis of renal tubular injury and interstitial fibrosis. The TUNEL assay, apoptosis-related enzyme caspase-3 mRNA detected by RT-PCR, and its enzymatic activity were analysed for thepossible detections of cell apoptosis.Results CsA-treated rats displayed increased apoptosis of the tubular and interstitial cells, in comparison with vehicle-treated controls ( 18.3 ±4. 6 vs 4. 8 ± 1.3 cells/mm^2, P < 0.05 ). In comparision with animals treated by CsA, animals treated with CsA plus tea polyphenols demonstratedsignificantly improved levels of creatinine clearance (0. 12±0.03 vs 0.22±0.02 ml·min^-1 . 100g^-1body weight, P < 0. 05 ), tubular injury (2.29 ± 0.43 vs 1.42±0. 26, P < 0. 05 ), and interstitial fibrosis (2.83±0. 20 vs 1.46 ±0. 19, P < 0. 05 ), and showed a statistically significant decrease intubular and interstitial cell apoptosis (18.3±4. 6 vs 7. 7±2. 1 cells/mm^2, P < 0. 05). The expression of caspase-3 mRNA and caspase-3 activity was significantly higher in the CsA-treated group than that of the CsA plus tea polyphenols (TP)-treated group ( P <0.05).Conclusion These results suggested that tea polyphenols significantly inhibits apoptosis of the tubular and interstitial cells in rats with cyclosporine-inced chronic nephrotoxicity, and that tea polyphenols may be useful to prevent CsA-associated kidney toxicity.
抑制作用的茶多酚对大鼠肾细胞凋亡的实验对象患有环孢素A<span left-pos="110|30" right-pos="110|30" space="1|
" style="color: rgb(51, 51, 51); font-family: arial; line-height: 22px; ">慢性肾毒性
目的探讨茶多酚对抑制肾细胞凋亡在大鼠的试验的受试者患环孢素A（CsA）诱发的慢性肾毒性。方法四组大鼠CsA慢性肾毒性分别用车辆的橄榄油，茶多酚，CSA和茶多酚联合CsA。在第二十八天的治疗结束，得到24小时尿液和血液样本，和动物处死。血清和尿液样品进行了分析，肌酐清除率，肾组织用于肾小管损伤及间质纤维化的病理分析。TUNEL法检测凋亡相关酶Caspase-3 mRNA，通过RT-PCR检测，和酶的活性进行了分析检测细胞凋亡的可能。结果显示细胞凋亡增加CsA处理的大鼠肾小管间质细胞，与车辆处理的对照组相比（18.3±4。6比4。8±1.3细胞/毫米^ 2，P <；0.05）。用CsA处理后的动物比较，CsA加茶多酚demonstratedsignificantly改善肌酐清除率水平治疗的动物（0。12±0.03 vs 0.22±0.02毫升·^ - 1分钟。100g ^ - 1body重量，P <；0。05），肾小管损伤（2.29±0.43 vs 1.42±0。26，P <；0。05），和间质纤维化（2.83±0。20比1.46±0。19，P <；0。05），并表现出统计上的显着减少管内和间质细胞凋亡（18.3±4。6比7。7±2。1个细胞/ mm ^ 2，P <；0。05。Caspase-3 mRNA和Caspase-3活性的表达在CsA治疗组明显高于CsA加茶多酚（TP）治疗组（P <；0.05）。结论这些结果表明，茶多酚能显著抑制肾小管间质细胞凋亡与环孢素A慢性肾毒性大鼠细胞，和茶多酚可以预防CsA肾毒性有关联。
抑制作用的茶多酚对大鼠肾细胞凋亡的实验对象患有环孢素A<span left-pos="110|30" right-pos="110|30" space="1|
">慢性肾毒性
目的探讨茶多酚对抑制肾细胞凋亡在大鼠的试验的受试者患环孢素A（CsA）诱发的慢性肾毒性。方法四组大鼠CsA慢性肾毒性分别用车辆的橄榄油，茶多酚，CSA和茶多酚联合CsA。在第二十八天的治疗结束，得到24小时尿液和血液样本，和动物处死。血清和尿液样品进行了分析，肌酐清除率，肾组织用于肾小管损伤及间质纤维化的病理分析。TUNEL法检测凋亡相关酶Caspase-3 mRNA，通过RT-PCR检测，和酶的活性进行了分析检测细胞凋亡的可能。结果显示细胞凋亡增加CsA处理的大鼠肾小管间质细胞，与车辆处理的对照组相比（18.3±4。6比4。8±1.3细胞/毫米^ 2，P <；0.05）。用CsA处理后的动物比较，CsA加茶多酚demonstratedsignificantly改善肌酐清除率水平治疗的动物（0。12±0.03 vs 0.22±0.02毫升·^ - 1分钟。100g ^ - 1body重量，P <；0。05），肾小管损伤（2.29±0.43 vs 1.42±0。26，P <；0。05），和间质纤维化（2.83±0。20比1.46±0。19，P <；0。05），并表现出统计上的显着减少管内和间质细胞凋亡（18.3±4。6比7。7±2。1个细胞/ mm ^ 2，P <；0。05。Caspase-3 mRNA和Caspase-3活性的表达在CsA治疗组明显高于CsA加茶多酚（TP）治疗组（P <；0.05）。结论这些结果表明，茶多酚能显著抑制肾小管间质细胞凋亡与环孢素A慢性肾毒性大鼠细胞，和茶多酚可以预防CsA肾毒性有关联。追问大神，有再长一点的吗？3000字左右的，若能帮我，再给你加50，呵呵！
追答天哪，太难。没办法。对不起。采纳吧，这么多已经很好了
